Looking for research supporting name brand Keppra over generic

I am looking for research or articles that support the safety issues surrounding the Keppra generic for seizures. A couple years ago I had found such an article on the Epilepsy Foundation's site, but now I can't seem to locate it.

I have been fighting to get my insurance to cover my brand name Keppra for a couple years now. They want me to take the generic and only cover a very small percentage of the name brand which is driving our bank account into the ground. However, my neurologist has warned me against dosing issues surrounding the generic that I'm sure some of you are aware of. I'm gaining support in the form of a rep who is willing to fight for me, but I need to submit a letter along with anything I can to prove my case.

I'm googling like crazy right now, but if anyone has insight, please let me know!!
Thank you in advance!

I've only been on the generic and have had break through seizures. I am very curious as to what you find out. I'm a newbie so I will be following this thread. I hope you find some solid info!

Essentially, generic medications in general aren't as reliable in the amount and stabillity of the drug in them simply because they come from many different manufacturers who all have different processes. So, a pill you get one month might be different from the pill you get next month. This isn't a big deal with prescriptions like antibiotics or whatever, but in seizure medication, small fluctuations are a big deal and can cause breakthroughs. The problem is, many insurance agencies won't cover much of the name brand since a generic exists. I've never taken the generic because of the risk.
Here's a link I have found that you could look at:
http://epilepsytalk.com/2010/07/17/keppra-generic-seizure-drug-contributing-to-more-seizures-side-effects-and-death/

Hi Beth,

I completely agree that insurance should pay for your safest option! Good for you, for fighting for this.

There was a very recent study on Keppra-to-generic switching, published in Epilepsia. Almost half of the people forced to switch to generics were then switched BACK to Keppra by their doctors due to adverse effects of the generic. (I don't want to raise a panic about generics--I've been told that starting on generics and staying on a generic from a single manufacturer is FINE as long as it's working, but switching from a brand to a generic, or getting switched from one manufacturer's generic to another, is risky.)

Here's a link to the citation. (If you can't access the article online, just message me and I'll send it to you as an attachment.) http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2011.03025.x/full

And here's the Epilepsy Foundation's position statement on generic substitution:
http://www.epilepsyfoundation.org/getinvolved/advocacy/positionstatements/genedrev.cfm

Finally, here are a few links to articles that may or may not help your case; I haven't read them, but I have a university subscription that will let me download any of these articles for you if you need them. Just let me know if you want 'em!
http://www.ingentaconnect.com/content/adis/cns/2004/00000018/00000010/art00001

http://www.theannals.com/content/45/5/e27.short

I hope that's some help! Your materials will probably be useful to others in similar situations, so I wonder if you'd consider posting them here when you're done?

Thank you!