Post - op

Sadie is a 14 yr old girl and because they put her in a pentobarbital coma after her first surgery she went through some really nasty withdrawal even with methadone and morphine rescue doses and Valium and a ton of other medicines she suffered. Lately she has been very agressive and angry (since school started). I am at a loss as to if this is from the TBI , radiation, medications, hormones, or normal teenager stuff. She was admitted back into the hospital for 2 weeks recently and they took her off of two medications and added a mood stabilizer which has helped tremendously but, I am wondering if this has effected anyone else?